According to Duotrope, I sent off my 500th short story submission today.
That's actually a bit short of the mark, as there are quite a few places I've submitted stories to that aren't listed on Duotrope, for one reason or another. My guess is it's more like 600, if you go all the way back to my first rejections back in college.
Still, the number at the top of the page is a good round one. But I don't know if I should laugh or cry.